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Complement Pathway, Classical: Complement activation initiated by the binding of Complement c1 to Antigen-antibody complexes at the Complement c1q subunit. This leads to the sequential activation of Complement c1r and Complement c1s subunits. Activated C1s cleaves Complement c4 and Complement c2 forming the membrane-bound classical C3 convertase (C4b2a) and the subsequent C5 convertase (C4b2a3b) leading to cleavage of Complement c5 and the assembly of Complement membrane attack complex.

Evaluation of the Interplay Between the Complement Protein C1q and Hyaluronic Acid in Promoting Cell Adhesion

1Department of Life Sciences, University of Trieste, 2Institute for Maternal and Child Health, IRCCS (Istituto di Ricovero e Cura a Carattere Scientifico) Burlo Garofolo, 3Department of Medical, Surgical and Health Science, University of Trieste

JoVE 58688

 Immunology and Infection

High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment

1Department of Immunology, Reims University Hospitals, Robert Debré Hospital, 2Faculty of Medicine, LRN EA 4682, University of Reims Champagne-Ardenne, 3Department of Internal Medicine and Geriatrics, Reims University Hospitals, Maison Blanche Hospital, 4Faculty of Medicine, EA 3797, University of Reims Champagne-Ardenne

JoVE 56012

 Genetics
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