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Glial Cells

JoVE 10843

Glial cells are one of the two main types of cells in the nervous system. Glia cells comprise astrocytes, oligodendrocytes, microglia, and ependymal cells in the central nervous system, and satellite and Schwann cells in the peripheral nervous system. These cells do not communicate via electrical signals like neurons do, but they contribute to virtually every other aspect of nervous system function. In humans, the number of glial cells is roughly equal to the number of neurons in the brain. Glia in the central nervous system (CNS) include astrocytes, oligodendrocytes, microglia, and ependymal cells. Astrocytes are the most abundant type of glial cell and are found in organized, non-overlapping patterns throughout the brain, where they closely associate with neurons and capillaries. Astrocytes play numerous roles in brain function, including regulating blood flow and metabolic processes, synaptic ion and pH homeostasis, and blood-brain barrier maintenance. Another specialized glial cell, the oligodendrocyte, forms the myelin sheath that surrounds neuronal axons in the CNS. Oligodendrocytes extend long cellular processes that wrap around axons multiple times to form this coating. Myelin sheath is required for proper conduction of neuronal signaling and greatly increases the speed at which these messages travel. Microglia—known as the macrop

 Core: Biology

An In Vivo Mouse Model to Measure Naïve CD4 T Cell Activation, Proliferation and Th1 Differentiation Induced by Bone Marrow-derived Dendritic Cells

1LamImSys Lab, Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), 2LamImSys Lab, Instituto de Investigación Sanitaria Hospital 12 de Octubre (imas12), 3CIBER de Enfermedades Cardiovasculares

JoVE 58118

 Immunology and Infection

Setup of Capillary Electrophoresis-Inductively Coupled Plasma Mass Spectrometry (CE-ICP-MS) for Quantification of Iron Redox Species (Fe(II), Fe(III))

1Research Unit Analytical BioGeoChemistry, Helmholz Zentrum München-German Research Center for Environmental Health, 2Department of Hematology and Medical Oncology, University Medical Center Göttingen (UMG), 3Institute of Pathology, University Medical Center Göttingen (UMG), 4RECIPE Chemicals + Instruments GmbH


JoVE 61055

 Chemistry
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