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HLA-A Antigens: Polymorphic class I human histocompatibility (Hla) surface antigens present on almost all nucleated cells. At least 20 antigens have been identified which are encoded by the A locus of multiple alleles on chromosome 6. They serve as targets for T-cell cytolytic responses and are involved with acceptance or rejection of tissue/organ grafts.

Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation

1Division of Nephrology and Hypertension, and the Center for Kidney Research and Therapeutics at the Feinberg Cardiovascular Research Institute, Northwestern University Feinberg School of Medicine, 2Surgery-Organ Transplantation, Northwestern University Feinberg School of Medicine, 3School of Biological Sciences and Medical Engineering, Southeast University

JoVE 56278

 Biochemistry

Hardy-Weinberg & Genetic Drift- Concept

JoVE 10559

Evolutionary change is interesting and important to study, but changes in populations occur over long periods of time and in huge physical spaces and are therefore very difficult to measure. In general, studying phenomena like this requires the use of mathematical models which are built using parameters that can be conveniently measured. These models are then used to make predictions about how …

 Lab Bio

Natural Selection- Concept

JoVE 10632

Fitness

Widespread variation of phenotypes in natural populations provides the raw material for evolution, which is the change in the inherited traits of populations over successive generations. Natural selection is one of the main mechanisms of evolution and requires variable traits to be heritable and associated with differential survival and/or reproductive success. Phenotypes that…

 Lab Bio

Use of Interferon-γ Enzyme-linked Immunospot Assay to Characterize Novel T-cell Epitopes of Human Papillomavirus

1Department of Microbiology and Parasitology, College of Basic Medical Sciences, China Medical University, 2Department of Obstetrics and Gynecology, College of Medicine, University of Arkansas for Medical Sciences, 3Department of Pathology, College of Medicine, University of Arkansas for Medical Sciences

JoVE 3657

 Immunology and Infection

Selecting Multiple Biomarker Subsets with Similarly Effective Binary Classification Performances

1College of Computer Science and Technology, and Key Laboratory of Symbolic Computation and Knowledge Engineering of Ministry of Education, Jilin University, 2College of Software, Jilin University, 3Ultrasonography Department, China-Japan Union Hospital of Jilin University, 4Department of Pathogenobiology, College of Basic Medical Science, Jilin University

JoVE 57738

 Cancer Research

Use of Single Chain MHC Technology to Investigate Co-agonism in Human CD8+ T Cell Activation

1Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, 2Immunology Programme, Life Sciences Institute, National University of Singapore, 3Emerging Infectious Diseases Program, Duke-NUS Graduate Medical School, 4Singapore Immunology Network, A*STAR, 5NUS Graduate School for Integrative Sciences and Engineering (NGS), National University of Singapore, 6Department of Immunology, Wright-Fleming Institute, Imperial College London

JoVE 59126

 Immunology and Infection
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