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Integrins: A family of transmembrane glycoproteins (Membrane glycoproteins) consisting of noncovalent heterodimers. They interact with a wide variety of ligands including Extracellular matrix proteins; Complement, and other cells, while their intracellular domains interact with the Cytoskeleton. The integrins consist of at least three identified families: the cytoadhesin receptors(Receptors, Cytoadhesin), the leukocyte adhesion receptors (Receptors, Leukocyte adhesion), and the Very late antigen receptors. Each family contains a common beta-subunit (Integrin beta chains) combined with one or more distinct alpha-subunits (Integrin alpha chains). These receptors participate in cell-matrix and cell-cell adhesion in many physiologically important processes, including embryological development; Hemostasis; Thrombosis; Wound healing; immune and nonimmune defense mechanisms; and oncogenic transformation.
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