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Mice: The common name for the genus Mus.

Assessing Dexterity with Reaching Tasks

JoVE 5424

Reaching tasks are employed in behavioral neuroscience to investigate motor learning and forelimb dexterity. Much like human hands, rodents have dexterous forepaws, which are necessary for executing coordinated and precise motor movements. Experimenters may utilize food rewards to train rodents to reach and for testing their reaching abilities. These tasks help behavioral neuroscientist in…

 Behavioral Science

Noninvasive Blood Pressure Measurement Techniques

JoVE 10478

Source: Hamna J. Qureshi and Craig J. Goergen, Weldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana



Here we will highlight the key similarities and differences of noninvasive blood pressure measurement techniques between humans and rodents and examine the engineering principles…

 Biomedical Engineering

Photoacoustic Tomography to Image Blood and Lipids in the Infrarenal Aorta

JoVE 10395

Source: Gurneet S. Sangha and Craig J. Goergen, Weldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana


Photoacoustic tomography (PAT) is an emerging biomedical imaging modality that utilizes light generated acoustic waves to obtain compositional information from tissue. PAT can be used to image …

 Biomedical Engineering

Capacitance

JoVE 10296

Source: Yong P. Chen, PhD, Department of Physics & Astronomy, College of Science, Purdue University, West Lafayette, IN


This experiment will use commercial capacitors and a parallel plate capacitor to demonstrate the concept of capacitance. A capacitor stores opposite charges on two conductors, for example two opposite metal plates,…

 Physics II

An Overview of Genetic Engineering

JoVE 5552

Genetic engineering – the process of purposefully altering an organism’s DNA – has been used to create powerful research tools and model organisms, and has also seen many agricultural applications. However, in order to engineer traits to tackle complex agricultural problems such as stress tolerance, or to realize the promise of gene therapy for treating…

 Genetics

An Introduction to Organogenesis

JoVE 5334

Organogenesis is the process by which organs arise from one of three germ layers during the later stages of embryonic development. Researchers studying organogenesis want to better understand the genetic programs, cell-cell interactions, and mechanical forces involved in this process. Ultimately, scientists hope to use this knowledge to create therapies and artificial organs that will help…

 Developmental Biology

An Introduction to Stem Cell Biology

JoVE 5331

Cells that can differentiate into a variety of cell types, known as stem cells, are at the center of one of the most exciting fields of science today. Stem cell biologists are working to understand the basic mechanisms that regulate how these cells function. These researchers are also interested in harnessing the remarkable potential of stem cells to treat human diseases.


Here,…

 Developmental Biology

Categories and Inductive Inferences

JoVE 10109

Source: Laboratories of Nicholaus Noles and Judith Danovitch—University of Louisville


It might be possible for the human brain to keep track of each individual person, place, or thing encountered, but that would be a very inefficient use of time and cognitive resources. Instead, humans develop categories. Categories are mental…

 Developmental Psychology

The ATP Bioluminescence Assay

JoVE 5653

In fireflies, the luciferase enzyme converts a compound called luciferin into oxyluciferin, and produces light or “luminescence” as a result. This reaction requires energy derived from ATP in order to proceed, so researchers have exploited the luciferase-luciferin interaction to gauge ATP levels in cells. Given ATP’s role as the cell’s currency of…

 Cell Biology

The TUNEL Assay

JoVE 5651

One of the hallmarks of apoptosis is the nuclear DNA fragmentation by nucleases. These enzymes are activated by caspases, the family of proteins that execute the cell death program. TUNEL assay is a method that takes advantage of this feature to detect apoptotic cells. In this assay, an enzyme called terminal deoxynucleotidyl transferase catalyzes the addition of dUTP…

 Cell Biology
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