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SNARE Proteins: A superfamily of small proteins which are involved in the Membrane fusion events, intracellular protein trafficking and secretory processes. They share a homologous Snare motif. The Snare proteins are divided into subfamilies: Qa-snares; Qb-snares; Qc-snares; and R-Snares. The formation of a Snare complex (composed of one each of the four different types Snare domains (Qa, Qb, Qc, and R)) mediates Membrane fusion. Following membrane fusion Snare complexes are dissociated by the NSFs (N-Ethylmaleimide-sensitive factors), in conjunction with Soluble nsf attachment protein, i.e., SNAPs (no relation to Snap 25.)

SNARE-mediated Fusion of Single Proteoliposomes with Tethered Supported Bilayers in a Microfluidic Flow Cell Monitored by Polarized TIRF Microscopy

1Department of Cellular and Molecular Physiology, Yale University School of Medicine, 2Nanobiology Institute, Yale University, 3Department of Molecular Biophysics and Biochemistry, Yale University, 4Laboratoire de Neurophotonique, Université Paris Descartes, Faculté des Sciences Fondamentales et Biomédicales, Centre National de la Recherche Scientifique (CNRS)

JoVE 54349


 Neuroscience

Normothermic Ex Situ Heart Perfusion in Working Mode: Assessment of Cardiac Function and Metabolism

1Department of Surgery, Faculty of Medicine, University of Alberta, 2Department of Pediatrics, Faculty of Medicine, University of Alberta, 3Department of Biomedical Engineering, Faculty of Medicine, University of Alberta, 4Department of Mechanical Engineering, Faculty of Engineering, University of Alberta, 5Department of Chemical and Materials Engineering, Faculty of Engineering, University of Alberta, 6Canadian National Transplant Research Program, 7Department of Physiology, Faculty of Medicine, University of Alberta

JoVE 58430


 Medicine

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