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Tissue Inhibitor of Metalloproteinase-2: A member of the family of Tissue inhibitor of metalloproteinases. It is a 21-kDa nonglycosylated protein found in tissue fluid and is secreted as a complex with progelatinase A by human fibroblast and uncomplexed from alveolar macrophages. An overexpression of Timp-2 has been shown to inhibit invasive and metastatic activity of tumor cells and decrease tumor growth in vivo.
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