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1Jiangsu Province Key Laboratory of Anesthesiology, Jiangsu Province Key Laboratory of Anesthesia and Analgesia Application Technology, NMPA Key Laboratory for Research and Evaluation of Narcotic and Psychotropic Drugs, School of Anesthesiology,Xuzhou Medical University2Department of Anesthesiology,the Eye & ENT Hospital of Fudan University Shanghai3Department of Anesthesiology, Shanghai Tenth People’s Hospital,Tongji University School of Medicine