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JoVE Journal Neuroscience
En enkel komposit Fenotyp Scoring System för utvärdering musmodeller av cerebellär ataxi
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En enkel komposit Fenotyp Scoring System för utvärdering musmodeller av cerebellär ataxi

Article DOI: 10.3791/1787-v • 07:33 min • May 21st, 2010
May 21st, 2010 •
1, 2, 1, 2, *3, *2
1Department of Biochemistry, University of Washington, 2Department of Neurology, University of Washington, 3Division of Genetics, Departments of Pediatrics and Cellular and Molecular Medicine, and the Institute for Genomic Medicine, University of California, San Diego - Rady Children’s Hospital
* These authors contributed equally

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Vi beskriver ett protokoll för snabbare och känsligare kvantifiering av sjukdomens svårighetsgrad i musmodeller av cerebellär ataxi. Åtgärderna omfattar bakbenen knäppa, avsats test, gång och kyfos. Detta protokoll diskriminerar effektivt mellan drabbade och icke drabbade, och upptäcker utvecklingen av drabbade individer över tid.

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JUPITER neurovetenskap Neurodegeneration mus beteende analys cerebellär ataxi polyglutamine sjukdom
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