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JoVE Journal
Neuroscience

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Systemic and Local Drug Delivery for Treating Diseases of the Central Nervous System in Rodent Models
 
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Systemic and Local Drug Delivery for Treating Diseases of the Central Nervous System in Rodent Models

Article DOI: 10.3791/1992-v 11:52 min August 16th, 2010
August 16th, 2010

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Summary

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Click here for the English version.

Thorough preclinical testing of drugs that act in the central nervous system often involves assessing and comparing drug biodistribution in association with specific routes of administration. Here, three commonly used methods of systemic delivery (intravenous, intraperitoneal, and oral) as well as a method for local delivery (convection-enhanced delivery) are demonstrated in mice.

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Systemic Drug Delivery Local Drug Delivery Central Nervous System Diseases Rodent Models Therapeutic Efficacy Routes Of Administration Agent Biodistribution Systemic Delivery Approaches Local Delivery Methods Intravenous Injection Intraperitoneal Injection Oral Gavage Convection-enhanced Delivery (CED) Fluorescently-labeled Compounds In Vivo Imaging
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