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Journal / Immunology and Infection / Detection of Neu1 Sialidase Activity in…
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Immunology and Infection

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JoVE Journal Immunology and Infection
Detection of Neu1 Sialidase Activity in Regulating TOLL-like Receptor Activation
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Detection of Neu1 Sialidase Activity in Regulating TOLL-like Receptor Activation

Article DOI: 10.3791/2142-v • 09:05 min • September 7th, 2010
September 7th, 2010 •
*1, *1, *1, *1, *1, 1, *1
1Department of Microbiology and Immunology, Queen's University - Kingston, Ontario
* These authors contributed equally

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The sialidase assay is a simple technical approach that will elucidate novel molecular mechanism(s) of TLR sensors of microbial infections and involvement in inflammatory diseases at the receptor level on the cell surface of live macrophages.

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Neu1 Sialidase Activity TOLL-like Receptor Activation Mammalian Toll-like Receptors Pathogen-associated Molecular Patterns Infectious Diseases Inflammatory Diseases Autoimmune Diseases Structural Integrity Of Sensor Receptors Ligand Interactions Signaling Components Immunological Protection Disease Modification Ligand-induced TLR Activation Neu1 Sialidase Activation Neurotrophin Receptors TrkA TrkB Matrix Metalloproteinase-9 (MMP-9) Sialidase Assay
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