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Immunology and Infection

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Ratos Transnuclear com pré-definidos T Especificidades receptor da célula contra a Toxoplasma gondii Obtidos Via TNCS

Article DOI: 10.3791/2168-v • 13:37 min • September 30th, 2010
September 30th, 2010 •
1, 1, 1,2, 1, 1,3, 1,3
1Whitehead Institute for Biomedical Research, 2Departments of Microbiology and Biological Sciences, National University of Singapore, 3Department of Biology, Massachusetts Institute of Technology

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Demonstramos aqui que a reprogramação epigenética via transferência nuclear de células somáticas (TNCS) pode ser usado como uma ferramenta para gerar modelos de ratos com pré-definidos receptor de células T (TCR) especificidades. Estes ratos transnuclear expressar a TCR correspondente do seu lócus endógeno sob o controle do promotor endógeno.

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Biologia do Desenvolvimento edição 43 SCNT imunologia TCR BCR o modelo de mouse transnuclear
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