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Medicine

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In vivo Near Infrared Fluorescence (NIRF) Intravascular Molecular Imaging of Inflammatory Plaque, a Multimodal Approach to Imaging of Atherosclerosis
 

In vivo Near Infrared Fluorescence (NIRF) Intravascular Molecular Imaging of Inflammatory Plaque, a Multimodal Approach to Imaging of Atherosclerosis

Article DOI: 10.3791/2257-v 09:44 min August 4th, 2011
August 4th, 2011

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Summary

We detail a new near-infrared fluorescence (NIRF) catheter for 2-dimensional intravascular molecular imaging of plaque biology in vivo. The NIRF catheter can visualize key biological processes such as inflammation by reporting on the presence of plaque-avid activatable and targeted NIR fluorochromes. The catheter utilizes clinical engineering and power requirements and is targeted for application in human coronary arteries. The following research study describes a multimodal imaging strategy that utilizes a novel in vivo intravascular NIRF catheter to image and quantify inflammatory plaque in proteolytically active inflamed rabbit atheromata.

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In Vivo Near Infrared Fluorescence NIRF Intravascular Molecular Imaging Inflammatory Plaque Atherosclerosis Vascular Response Injury Inflammatory Response Macrophages Accumulation Lipid-laden Intra-luminal Plaque Smooth Muscle Cell Proliferation Narrowing Of Vessel Lumen Vulnerable Plaques Acute Myocardial Infarction Molecular Imaging Clinical Tool Research Tool Visualization Of Inflammation Biological Processes High-risk Plaques Pharmacotherapeutics MRI PET Carotid Arteries Coronary Arteries High-resolution Optical Imaging Strategies
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