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The Application Of Permanent Middle Cerebral Artery Ligation in the Mouse
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The Application Of Permanent Middle Cerebral Artery Ligation in the Mouse

Article DOI: 10.3791/3039-v • 08:28 min • July 25th, 2011
July 25th, 2011 •
1, 2, 3
1Department of Pharmacology and Physiology, University of Rochester, 2Department of Neurology, University of Alabama at Birmingham, 3Departments of Anesthesiology, Pharmacology and Physiology, University of Rochester

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Middle cerebral artery (MCA) ligation is a technique to study focal cerebral ischemia in animal models. In this method, the middle cerebral artery is exposed by craniotomy and ligated by cauterization. This method gives highly reproducible infarct volumes and increased post-operative survival rates compared to other methods available.

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Permanent MCA Ligation Focal Cerebral Ischemia Stroke Animal Models PMCAo Craniotomy Electrocoagulation Infarcts Cortical Regions Striatal Regions Neuroprotective Compounds Reproducible Infarcts Post-survival Rates MCA Artery
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