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Utvikling av en ensidig-lesioned 6-OHDA mus modell av Parkinsons sykdom
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Utvikling av en ensidig-lesioned 6-OHDA mus modell av Parkinsons sykdom

Article DOI: 10.3791/3234-v • 10:09 min • February 14th, 2012
February 14th, 2012 •
1, 1, 1
1Centre for Neurobiology of Stress, Dept Biological Sciences, University of Toronto at Scarborough

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En protokoll for å utføre ensidige 6-OHDA lesjoner i mediale forebrain bunten i mus er beskrevet. Denne metoden har lav dødelighet (13,3%) med 89% av de overlevende dyrene viser> 95% tap av striatale banene dopamin og 90,63 ± -4,02% ipsiversive roterende bias mot siden av lesjonen.

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Medisin mus 6-OHDA Parkinsons sykdom mediale forebrain bunt unilateral
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