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JoVE Journal Bioengineering
Formulation of Diblock Polymeric Nanoparticles through Nanoprecipitation Technique
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Formulation of Diblock Polymeric Nanoparticles through Nanoprecipitation Technique

Article DOI: 10.3791/3398-v • 06:48 min • September 20th, 2011
September 20th, 2011 •
1,2, 1,2, 1,2, 1,2, 1,2, 1,2, 1,2
1Laboratory of Nano- and Translational Medicine, Department of Radiation Oncology, Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, 2Carolina Center for Nanotechnology Excellence, University of North Carolina

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This article describes a nanoprecipitation method to synthesize polymer-based nanoparticles using diblock co-polymers. We will discuss the synthesis of diblock co-polymers, the nanoprecipitation technique, and potential applications.

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Formulation Diblock Polymeric Nanoparticles Nanoprecipitation Technique Nanotechnology Particles Nanoparticles Engineered Size Composition Surface Chemistry Cargo Properties Solubility Diffusivity Biodistribution Release Characteristics Immunogenicity Drug Delivery Imaging Cell Biology Technical Barrier Polymer-based Nanoparticle Platform Hydrophobic Domain Hydrophilic Domain PLGA PEG Conjugation Reaction EDC/NHS Chemistry Polymer Purification Process Self-assemble Hydrophobic-hydrophilic Interactions Versatile Nanoparticle
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