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Enhancement of Apoptotic and Autophagic Induction by a Novel Synthetic C-1 Analogue of 7-deoxypancratistatin in Human Breast Adenocarcinoma and Neuroblastoma Cells with Tamoxifen

Article DOI: 10.3791/3586-v • 19:44 min • May 30th, 2012
May 30th, 2012 •
1, 2, 2, 1
1Department of Chemistry and Biochemistry, University of Windsor, 2Chemistry Department and Centre for Biotechnology, Brock University

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Summary
Automatic Translation

We have synthesized a novel analogue of pancratistatin with comparable anti-cancer activity as native pancratistatin; interestingly, combinatory treatment with tamoxifen yielded a drastic enhancement in apoptotic and autophagic induction by mitochondrial targeting with minimal effect on noncancerous fibroblasts. Thus, JCTH-4 in combination with tamoxifen could provide a safe anti-cancer therapy.

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Apoptotic Induction Autophagic Induction Synthetic C-1 Analogue 7-deoxypancratistatin Breast Adenocarcinoma Neuroblastoma Cells Tamoxifen Anti-cancer Treatment Ionizing Radiation DNA Damage Selective Apoptosis Pancratistatin JCTH-4 Autophagy Malignancies Pro-survival Mechanism Pro-death Mechanism Chemotherapy Cell Death MCF7 Cells SH-SY5Y Cells
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