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Journal / Medicine / Il CYP2D6 modello animale: come indurre epatite…
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Il CYP2D6 modello animale
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Il CYP2D6 modello animale: come indurre epatite autoimmune in topi

Article DOI: 10.3791/3644-v • 09:03 min • February 3rd, 2012
February 3rd, 2012 •
1, 1, 1
1Pharmazentrum Frankfurt / ZAFES, Goethe University Hospital Frankfurt

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Infezione di topi con uno Adenovirus che esprime il autoantigene maggiore umano citocromo P450 2D6 (hCYP2D6) riconosciuti da sieri di pazienti affetti da di tipo 2 risultati epatite autoimmune in una forma persistente di autoimmune-mediata malattia epatica caratterizzata da estensiva epatite, fibrosi e la generazione di uno CYP2D6 -specifica risposta immunitaria.

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Medicina autoimmunità fegato autoantigene la fibrosi la perfusione
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