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O modelo animal CYP2D6
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O modelo animal CYP2D6: Como induzir hepatite auto-imune em ratos

Article DOI: 10.3791/3644-v • 09:03 min • February 3rd, 2012
February 3rd, 2012 •
1, 1, 1
1Pharmazentrum Frankfurt / ZAFES, Goethe University Hospital Frankfurt

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Infecção de camundongos com um Adenovírus expressando o autoantígeno major humano do citocromo P450 2D6 (hCYP2D6) reconhecidas pelos soros de pacientes que sofrem a partir de tipo 2 resultados da hepatite auto-imunes em uma forma persistente da auto-imune-mediada doença do fígado caracterizada por extenso hepatite fibrose, e de geração de um CYP2D6 -específica resposta imune.

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Emissão de Medicina 60 auto-imunidade fígado autoantígeno fibrose a perfusão
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