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DNA-Vektor-basierte RNA-Interferenz, um Genfunktionen in Cancer Study

Article DOI: 10.3791/4129-v • 13:10 min • June 4th, 2012
June 4th, 2012 •
1, 1, 1, 2, 1
1Department of Cancer Biology and Comprehensive Cancer Center, Wake Forest University School of Medicine, 2Department of Pathology and Comprehensive Cancer Center, Wake Forest University School of Medicine

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RNA-Interferenz (RNAi) besitzt viele Vorteile gegenüber der Gen-Knockout und wurde allgemein als ein Werkzeug in der Gen-funktionelle Studien verwendet. Die Erfindung des DNA-Vektor-basierte RNAi-Technologie hat langfristig und induzierbare Gen Knockdown möglich gemacht haben, und erhöhte auch die Machbarkeit von Gen-Silencing

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Cancer Biology Ausgabe 64 Medizin Genetik RNAi shRNA Gen-Silencing Maus-Xenograft Tumorbildung
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