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Immunology and Infection

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JoVE Journal Immunology and Infection
Bruke BLT humanisert Mouse som en stamcelle basert Gene Therapy Tumor Model
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Bruke BLT humanisert Mouse som en stamcelle basert Gene Therapy Tumor Model

Article DOI: 10.3791/4181-v • 06:59 min • December 18th, 2012
December 18th, 2012 •
1,2,3, 1,2, 1,2, 1,2, 4, 4, 1,2,3, 1,2,5
1Department of Medicine, Division of Hematology-Oncology, David Geffen School of Medicine at UCLA, 2UCLA AIDS Institute, 3Eli & Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA, 4Department of Medical and Molecular Pharmacology, David Geffen School of Medicine at UCLA, 5Department of Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine at UCLA

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Generering og karakterisering av tumor spesifikke T-celler ved hjelp av humaniserte mus er beskrevet her. Menneskelig thymic vev og genmodifiserte menneskelige blodkreft stamceller er transplantert inn immunsupprimerte mus. Dette resulterer i rekonstituering av en konstruert menneskets immunsystem muliggjør in vivo undersøkelse av anti-tumor immunrespons.

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Kreft biologi Stem Cell Biology immunologi Biomedical Engineering medisin bioteknologi genetikk Oncology humanisert mus stamcelletransplantasjon stamceller, T-celler kreft dyremodell
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