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JoVE Journal
Immunology and Infection

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JoVE Journal Immunology and Infection
Multi-target Parallel Processing Aanpak voor Gene-to-structuur bepalen van de Influenza Polymerase PB2 Subunit
ExCYT: A Graphical User Interface for Streamlining Analysis of High-Dimensional Cytometry Data
Journal (Immunology and Infection)
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Non-surgical Intratracheal Instillation of Mice with Analysis of Lungs and Lung Draining Lymph Nodes by Flow Cytometry
Journal (Immunology and Infection)
Non-surgical Intratracheal Instillation of Mice with Analysis of Lungs and Lung Draining Lymph Nodes by Flow Cytometry
 
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Multi-target Parallel Processing Aanpak voor Gene-to-structuur bepalen van de Influenza Polymerase PB2 Subunit

Article DOI: 10.3791/4225-v • 22:11 min • June 28th, 2013
June 28th, 2013 •
*1, *2, 2, 3, 4, 5, 6, 7, 5, 8, 9
1Protein Crystallization Lab, Emerald Bio, 2Molecular Biology Lab, Emerald Bio, 3Scientific Sales Representative, Emerald Bio, 4Group Leader II, Emerald Bio, 5Group Leader I, Emerald Bio, 6Chair of Advisory Board, Emerald Bio, 7Director of Multi-Target Services, Emerald Bio, 8Senior Project Leader, Emerald Bio, 9Project Leader II & SSGCID Site Manager, Emerald Bio
* These authors contributed equally

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Structure-based drug design speelt een belangrijke rol in de ontwikkeling van geneesmiddelen. Nastreven van meerdere doelen tegelijkertijd verhoogt de kans op succes voor lood ontdekking. Het volgende artikel belicht hoe de Seattle Structural Genomics Centrum Infectieziektebestrijding maakt gebruik van een multi-target benadering voor gen-tot-structuur bepaling van de PB2 influenza A subunit.

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Infectie Structurele Biologie Virologie Genetica Geneeskunde Biomedische Technologie Moleculaire Biologie Infectieziekten Microbiologie Genomics high throughput multi-targeting structurele genomica proteïne kristallisatie zuivering eiwitproductie X-ray kristallografie gen Componist Protein Maker expressie, Fermentatie griep virus vector plasmide cel celkweek PCR sequencing
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