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Kvantitativ analyse av Chromatin Proteomes i sykdom
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Kvantitativ analyse av Chromatin Proteomes i sykdom

Article DOI: 10.3791/4294-v • 08:11 min • December 28th, 2012
December 28th, 2012 •
1, 1, 1, 1, 1,2,3, 1,4
1Department of Anesthesiology, David Geffen School of Medicine at UCLA, 2Department of Medicine, David Geffen School of Medicine at UCLA, 3Department of Physiology, David Geffen School of Medicine at UCLA, 4Department of Internal Medicine, Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah

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Fremskritt innen massespektrometri har tillatt høy gjennomstrømning analyse av protein uttrykk og modifikasjon på en rekke vev. Kombinert med subcellulære fraksjonering og sykdom modeller, kvantitative massespektrometri og bioinformatikk kan avsløre nye egenskaper i biologiske systemer. Metoden er beskrevet her analyserer kromatin-assosierte proteiner i innstillingen av hjertesykdom og er lett anvendelig til andre

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Medisin Molecular Biology immunologi genetikk Genomics fysiologi Protein DNA Chromatin hjerte-og karsykdommer proteomikk massespektrometri
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