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Journal / Neuroscience / Generatie Topisch transgene Rats door
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Generatie Topisch transgene Rats door
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Generatie Topisch transgene Rats door

Article DOI: 10.3791/50146-v • 08:44 min • September 24th, 2013
September 24th, 2013 •
1, 2, 2, 3, 1
1Department of Neuropathology, Medical School Düsseldorf, 2Department of Molecular Genetics, Weizmann Institute for Science, 3Center of Behavioral Neuroscience, University of Düsseldorf

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Genen kunnen worden gemanipuleerd tijdens de ontwikkeling van de cortex of de hippocampus van de rat via in utero elektroporatie (IUE) op E16, om snelle en doelgerichte wijzigingen in neuronale connectiviteit mogelijk te maken voor latere studies van gedrag of neuropathologie bij volwassen dieren. Postnatale in vivo beeldvorming voor controle IUE succes uitgevoerd door bioluminescentie activerende co-getransfecteerd luciferase.

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Neurowetenschappen Hippocampus Geheugen Schizofrenie, Luciferase Disrupted-in-schizofrenie-1 (DISC1)
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