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Murine Spinotrapezius model om de invloed van arteriolaire Ligatie beoordelen op microvasculaire functie en Remodeling

Article DOI: 10.3791/50218-v • 16:43 min • March 3rd, 2013
March 3rd, 2013 •
*1, *1, 2, 3, 1, 4, 2, 1
1Department of Biomedical Engineering, University of Virginia, 2Department of Biomedical Engineering, California Polytechnic State University, 3Office of Animal Welfare, University of Virginia, 4Department of Biomedical Engineering & Institute for Computational Medicine, Johns Hopkins University
* These authors contributed equally

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We demonstreren a novel arteriële ligatie model in muizen spinotrapezius spier, inclusief een stap-voor-stap procedure en beschrijving van de vereiste instrumenten. We beschrijven de operatie en relevante uitkomstmaten met betrekking tot vasculaire netwerk remodeling en functionele vasodilatatie met intravitale en confocale microscopie.

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Biomedische Technologie geneeskunde anatomie fysiologie Chirurgie Immunologie Hematologie microvaten haarvaten arteriolen venulen vaatziekten ischemie spinotrapezius perifere vasculaire ziekte functionele vasodilatatie arteriolen ligatie schepen circulatie confocale microscopie diermodel
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