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Ischemia-reperfusion Model of Acute Kidney Injury and Post Injury Fibrosis in Mice
 

Ischemia-reperfusion Model of Acute Kidney Injury and Post Injury Fibrosis in Mice

Article doi: 10.3791/50495
August 9th, 2013 Usage Statistics

Summary August 9th, 2013

We describe models of moderate and severe ischemia-reperfusion-induced kidney injury in which the mice undergo unilateral renal pedicle clamping followed by simultaneous or delayed contralateral nephrectomy, respectively. These models consistently give rise to renal dysfunction and post-injury fibrosis, but injury severity and survival are dependent on mouse background, age and surgical equipment.

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