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JoVE Journal Bioengineering
One Minute, Sub-One-Watt Photothermal ablazione del tumore Utilizzando Porphysomes, intrinseca multifunzionale nanovesicles
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One Minute, Sub-One-Watt Photothermal ablazione del tumore Utilizzando Porphysomes, intrinseca multifunzionale nanovesicles

Article DOI: 10.3791/50536-v • 09:51 min • September 17th, 2013
September 17th, 2013 •
1,2,3, 4, 1,2,3
1Department of Pharmaceutical Sciences, University of Toronto, 2The Institute of Biomaterials and Biomedical Engineering, University of Toronto, 3Ontario Cancer Institute, Campbell Family Institute For Cancer Research and Techna Institute, 4Department of Biomedical Engineering, University at Buffalo, The State University of New York

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Abbiamo sviluppato nuovi nanovesicles multifunzionali intrinseche chiamati porphysomes, che hanno struttura-dipendente fluorescenza auto-estinzione e le proprietà fototermiche uniche, fungendo così gli agenti di terapia fototermica come potenti. Abbiamo formulato porphysomes utilizzando estrusione ad alta pressione e studiato l'efficacia della terapia photothermal in un modello di tumore xenotrapianto.

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Bioingegneria nanoparticelle Porphysome la terapia fototermica nanoparticelle porfirina
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