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A morte celular associada com mitose anormal observado por imagem confocal em células vivas Câncer
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A morte celular associada com mitose anormal observado por imagem confocal em células vivas Câncer

Article DOI: 10.3791/50568 • 15:53 min • August 21st, 2013
August 21st, 2013 •
1, 2,3, 4, 4, 5, 1,6, 2,3
1Cancer Research Center, Sheba Medical Center, 2The Neufeld Cardiac Research Institute, Tel-Aviv University, 3Department of Physiology and Pharmacology, Tel-Aviv University, 4Imaging Unit, Sackler Faculty of Medicine, Tel-Aviv University, 5Biotechnology and Cell Signaling, Ecole Superieure de Biotechnologie Strasbourg, 6Department of Human Molecular Genetics and Biochemistry, Tel-Aviv University

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A actividade citotóxica do fenantridina PJ-34 em células de cancro sujeitos a mitose foi documentada em tempo real por meio de imagem confocal vivo. PJ-34 erradicou o câncer de mama humano MDA-MB-231 células abrigam extra-centrossomas na mitose. Ao contrário de mitose bi-focal normal, o Extra-centrossomas não foram agrupados nos dois pólos do fuso na presença de PJ-34.

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Biologia do Câncer Medicina Biologia Celular Biologia Molecular Engenharia Biomédica Anatomia Fisiologia Genética Processos Neoplásicas Ações Farmacológicas imagem confocal Live extra-centrosomes agrupamento / de-clustering Mitotic morte celular Catastrophe PJ-34 infarto do miocárdio microscopia imagem
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