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Celledød forbundet med abnorme Mitosis Observeret ved konfokal Imaging i Live kræftceller
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Celledød forbundet med abnorme Mitosis Observeret ved konfokal Imaging i Live kræftceller

Article DOI: 10.3791/50568-v • 15:53 min • August 21st, 2013
August 21st, 2013 •
1, 2,3, 4, 4, 5, 1,6, 2,3
1Cancer Research Center, Sheba Medical Center, 2The Neufeld Cardiac Research Institute, Tel-Aviv University, 3Department of Physiology and Pharmacology, Tel-Aviv University, 4Imaging Unit, Sackler Faculty of Medicine, Tel-Aviv University, 5Biotechnology and Cell Signaling, Ecole Superieure de Biotechnologie Strasbourg, 6Department of Human Molecular Genetics and Biochemistry, Tel-Aviv University

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Den cytotoksiske aktivitet af phenanthridin PJ-34 i cancerceller undergår mitose blev dokumenteret i realtid ved levende konfokal billeddannelse. PJ-34 udryddet human brystkræft MDA-MB-231 celler, der huser ekstra-centrosomes i mitose. I modsætning til normal bi-omdrejningspunkt mitose blev de ekstra-centrosomes ikke grupperet i de to spindel poler i tilstedeværelse af PJ-34.

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Cancer Biology medicin cellebiologi molekylærbiologi Biomedical Engineering anatomi fysiologi genetik Neoplastiske Processer farmakologiske virkninger Levende konfokal billedbehandling Ekstra-centrosomes clustering / de-klyngedannelse Mitotisk Catastrophe celledød PJ-34 myokardieinfarkt mikroskopi billedbehandling
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