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Journal / Immunology and Infection / Analyser for identifisering av nye antivirale…
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Immunology and Infection

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JoVE Journal Immunology and Infection
Analyser for identifisering av nye antivirale midler mot blåtungevirus
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Analyser for identifisering av nye antivirale midler mot blåtungevirus

Article DOI: 10.3791/50820-v • 12:02 min • October 11th, 2013
October 11th, 2013 •
1, 2, 1
1Division of Infectious Diseases, Department of Medicine, University of Alabama at Birmingham, 2Molette Laboratory for Drug Discovery, Department of Chemistry and Biochemistry, Auburn University

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Tre analyser, inkludert den cytopatiske effekt (CPE)-baserte assay, dose-respons-analyse og Time-of-Addition (TOA) assay er blitt utviklet, optimalisert, validert og anvendt for å identifisere nye antivirale midler mot blutetonguevirus (BTV), samt som å bestemme mulige Mechanism-of-Handling (MoA) for nylig identifiserte antivirals.

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Immunologi Drug Discovery Drug Evaluation Prekliniske evalueringsstudier som tema Drug Evaluation forundersøkelser biologisk analyse Technology Pharmaceutical høy gjennomstrømming screening-analyser dyresykdommer etterforskningsteknikker Antiviral Effekt blåtungevirus cytopatisk effekt Dose respons Time-of-Tilsetting Mechanism-of-Handling
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