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Journal / Biology / Rato Genoma Engenharia Usando Nucleases Designer
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Rato Genoma Engenharia Usando Nucleases Designer
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Rato Genoma Engenharia Usando Nucleases Designer

Article DOI: 10.3791/50930-v • 12:04 min • April 2nd, 2014
April 2nd, 2014 •
1, 2, 2, 1
1Institute of Laboratory Animal Science, University of Zurich, 2Department of Genetics, Cell Biology & Development and Center for Genome Engineering, University of Minnesota

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Nucleases designers, tais como as nucleases de dedos de zinco (ZFNs) e activadores de transcrição, tal como nucleases efectoras (TALENS) pode ser utilizado para modificar o genoma de embriões préimplantação de ratinho por desencadear tanto a extremidade não homóloga de união (NHEJ) e recombinação homóloga (HR) vias. Estes avanços permitir a rápida geração de ratinhos com modificações genéticas precisas.

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Genetics Oocyte microinjeção nucleases Designer ZFN TALEN Engenharia Genoma
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