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Produktion af Apolipoprotein C-III Knockout Kaniner hjælp zinkfinger Nucleaser
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Produktion af Apolipoprotein C-III Knockout Kaniner hjælp zinkfinger Nucleaser

Article DOI: 10.3791/50957-v • 10:59 min • November 18th, 2013
November 18th, 2013 •
1, 1, 1, 1, 1, 2, 1
1Center for Advanced Models for Translational Sciences and Therapeutics, Department of Internal Medicine, University of Michigan Medical Center, 2Department of Molecular Pathology, University of Yamanashi

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Seneste udvikling i gen-targeting værktøjer gør produktionen af ​​knockout (KO) kaniner muligt. I det nuværende arbejde, vi genererede fem Apolipoprotein (Apo) C-III KO kaniner bruger Zink Finger Nucleaser (ZFN). Dette arbejde viste, at ZFN er en yderst effektiv metode til at producere KO kaniner.

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Medicine apolipoprotein C-III kaniner knockout zinkfinger nuklease hjertekarsygdomme lipidmetabolisme ApoCIII
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