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JoVE Journal
Bioengineering

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JoVE Journal Bioengineering

PLGA Nanoparticles Formed by Single- or Double-emulsion with Vitamin E-TPGS

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PLGA Nanoparticles Formed by Single- or Double-emulsion with Vitamin E-TPGS

Article DOI: 10.3791/51015-v • 12:48 min • December 27th, 2013

December 27th, 2013 •

Rebecca L. McCall¹, Rachael W. Sirianni¹

¹Barrow Brain Tumor Research Center, Barrow Neurological Institute

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Deutsch (German)
italiano (Italian)
русский (Russian)

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We describe the production and characterization of nanoparticles and microparticles composed of poly(lactic-co-glycolic acid) using vitamin E-TPGS as an emulsifier. By varying formulation parameters such as the concentration of emulsifier, it is possible to produce nanoparticles with mean diameters ranging from 220 nm to 1.98 µm.

Tags

PLGA Nanoparticles Drug Delivery Biodegradable Polymers FDA-approved Single-emulsion Double-emulsion Hydrophobic Drugs Hydrophilic Drugs Encapsulation Organic Phase Aqueous Phase Solvent Evaporation Centrifugation Lyophilization Long Term Storage Hydrolysis Reproducible Formation Equipment Variability Reagents Batch Emulsification Method Vitamin E-TPGS Emulsifying Agent Particle Morphology Size Determination Scanning Electron Microscopy (SEM)

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