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Início do Carcinoma de mama metastático por Segmentação do ductal Epithelium com Adenovírus-Cre
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Início do Carcinoma de mama metastático por Segmentação do ductal Epithelium com Adenovírus-Cre: Um Modelo Novel de camundongo transgênico do Câncer de Mama

Article DOI: 10.3791/51171-v • 07:14 min • March 26th, 2014
March 26th, 2014 •
*1, *1, 1, 1, 1, 1, 1, 2, 3, 4,5,6, 1
1Tumor Microenvironment and Metastasis Program, Wistar Institute, 2Department of Pathology and Lab Medicine, Perelman School of Medicine, University of Pennsylvania, 3Department of Microbiology and Immunology and Department of Genetics, Geisel School of Medicine at Dartmouth, 4Division of Endocrine and Oncologic Surgery, Department of Surgery, Perelman School of Medicine, University of Pennsylvania, 5Rena Rowan Breast Center, Abramson Cancer Center, University of Pennsylvania, 6Center for Advanced Medicine, University of Pennsylvania
* These authors contributed equally

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Ativação de mutações latentes com adenovírus-Cre no sistema ductal resultados mamárias em um câncer de mama metastático clinicamente relevante. Incorporação de um promotor YFP permite o rastreamento de células tumorais metastáticas distais. Este modelo é útil para estudar metástase latente, a imunidade anti-tumor, e para a concepção de novas imunoterapias para tratar o câncer de mama.

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Medicina Edição 85 camundongos transgênicos o câncer de mama metástase injeção intraductal mutações latentes adenovírus-Cre
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