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In Vivo L'imagerie optique de tumeurs cérébrales et l'arthrite Utilisation fluorescent SAPC-DOPS nanovésicules
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In Vivo L'imagerie optique de tumeurs cérébrales et l'arthrite Utilisation fluorescent SAPC-DOPS nanovésicules

Article DOI: 10.3791/51187-v • 09:04 min • May 2nd, 2014
May 2nd, 2014 •
1,2, 3, 1, 5,6, 5,6, 4, 4, 3, 1,2
1Division of Hematology-Oncology, Department of Internal Medicine, University of Cincinnati College of Medicine, 2Division of Human Genetics, University of Cincinnati College of Medicine, 3Department of Radiology, University of Cincinnati College of Medicine, 4Division of Rheumatology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, 5Solid Tumor Biology Program, James Comprehensive Cancer Center, The Ohio State University Medical Center, 6Department of Neurological Surgery, James Comprehensive Cancer Center, The Ohio State University Medical Center

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Nous décrivons un multi-angle de rotation du système optique d'imagerie (Maroi) pour la quantification in vivo d'un marqueur fluorescent émis par la saposine C (SAPC), dioléoylphosphatidylsérine (DOPS) nanovésicules. En utilisant des modèles murins de cancer et l'arthrite, nous montrons comment la Maroi analyse de la courbe du signal peut être utilisé pour la cartographie et la caractérisation biologique précis des processus pathologiques.

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Médecine Numéro 87 Saposine C (SAPC) dioléoylphosphatidylsérine (DOPS) tumeur cérébrale arthrite Fluorophore fluorescence l'imagerie optique multi-angle imagerie optique de rotation (Maroi)
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