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In Vivo Optisk avbildning av hjärntumörer och Artrit med fluorescerande SAPC-DOPS Nanovesicles
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In Vivo Optisk avbildning av hjärntumörer och Artrit med fluorescerande SAPC-DOPS Nanovesicles

Article DOI: 10.3791/51187-v • 09:04 min • May 2nd, 2014
May 2nd, 2014 •
1,2, 3, 1, 5,6, 5,6, 4, 4, 3, 1,2
1Division of Hematology-Oncology, Department of Internal Medicine, University of Cincinnati College of Medicine, 2Division of Human Genetics, University of Cincinnati College of Medicine, 3Department of Radiology, University of Cincinnati College of Medicine, 4Division of Rheumatology, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, 5Solid Tumor Biology Program, James Comprehensive Cancer Center, The Ohio State University Medical Center, 6Department of Neurological Surgery, James Comprehensive Cancer Center, The Ohio State University Medical Center

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Vi beskriver en multi-vinkel roterande optisk avbildning (Maroi) systemet för in vivo kvantifiering av en fluorescerande markör levereras av saposin C (SAPC)-dioleoylphosphatidylserine (DOPS) nanovesicles. Under användning musmodeller av cancer och artrit, visar vi hur signalkurvan analysen Maroi kan användas för noggrann kartläggning och biologisk karakterisering av sjukdomsprocesser.

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Medicin saposin C (SAPC) Dioleoylphosphatidylserine (DOPS) Hjärntumör artrit Fluorofor fluorescens optisk imaging Multi-vinkel roterande optisk avbildning (Maroi)
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