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En hög genomströmning MHC II-bindningsanalys för kvantitativ analys av peptidepitoper
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En hög genomströmning MHC II-bindningsanalys för kvantitativ analys av peptidepitoper

Article DOI: 10.3791/51308-v • 07:59 min • March 25th, 2014
March 25th, 2014 •
1, 2, 3, 1
1Thayer School of Engineering, Dartmouth College, 2Institute for Immunology and Informatics, University of Rhode Island, 3Department of Computer Science, Dartmouth College

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Biokemiska analyser med rekombinanta humana MHC II molekyler kan ge snabba, kvantitativa insikter immunogen epitop identifiering, radering eller design. Här används en peptid-MHC-II-bindningsanalys skalas till 384-brunnsplattor beskrivas. Denna kostnadseffektiva format ska vara användbar när det gäller protein deimmunization och vaccin design och utveckling.

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Biokemi Immunoassay Protein immunogenicitet MHC II T-cell-epitop hög genomströmning skärm Deimmunization Vaccine Design
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