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Manufacture of Concentrated, Lipid-based Oxygen Microbubble Emulsions by High Shear Homogenization and Serial Concentration
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Manufacture of Concentrated, Lipid-based Oxygen Microbubble Emulsions by High Shear Homogenization and Serial Concentration

Article DOI: 10.3791/51467-v • 13:17 min • May 26th, 2014
May 26th, 2014 •
1, 1, 2, 1
1Department of Cardiology, Boston Children's Hospital, Harvard Medical School, 2Department of Anesthesiology and Critical Care, Children's Hospital of Philadelphia, University of Pennsylvania

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Summary
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We describe methods for the manufacture of large volumes of lipid-based oxygen microbubbles (LOMs) designed for intravenous oxygen delivery using high-shear homogenization and serial concentration.

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Concentrated Lipid-based Oxygen Microbubble Emulsions High Shear Homogenization Serial Concentration Gas-filled Microbubbles Ultrasound Contrast Agents Drug Delivery Agents Sonication Mechanical Agitation Microfluidic Devices Homogenization Lipid-based Oxygen Microbubbles (LOMs) Oxygen Delivery Medical Emergencies Hypoxemia Organ Injury Cardiac Arrest Death Scaled-up Production Closed-loop High-shear Homogenizer 2 L Of Concentrated LOMs Mean Diameter Of 2 μm Rheologic Profile Blood Consistency Translational Research Labs
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