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JoVE Journal
Biology

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In Vitro Aggregation Analyser hjelp hyperfosforylert Tau Protein
 
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In Vitro Aggregation Analyser hjelp hyperfosforylert Tau Protein

Article DOI: 10.3791/51537
January 2nd, 2015

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Summary January 2nd, 2015

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Umodifiserte og hyperfosforylert tau proteiner ble brukt i to in vitro aggregering analyser for å avdekke hyperfosforylering avhengige rask aggregering kinetikk. Disse analysene bane vei for fremtidige skjermer for forbindelser som kan modulerer tilbøyelighet til hyperfosforylert tau for å danne fibriller som ligger til grunn for utviklingen av Alzheimers sykdom.

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