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Neuroscience

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JoVE Journal Neuroscience
Design and Fabrication of Ultralight Weight, Adjustable Multi-electrode Probes for Electrophysiological Recordings in Mice
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Design and Fabrication of Ultralight Weight, Adjustable Multi-electrode Probes for Electrophysiological Recordings in Mice

Article DOI: 10.3791/51675-v • 15:43 min • September 8th, 2014
September 8th, 2014 •
*1, *1, 1, 2, 2, 2, 1
1The Neuroscience Institute, New York University Langone Medical Center, 2Department of Brain and Cognitive Science, Massachusetts Institute of Technology
* These authors contributed equally

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Summary
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Understanding the neural substrates of behavior requires brain circuit ensemble recording. Because of its genetic tractability, the mouse offers a model for circuit dissection and disease mimicry. Here, a method of designing and fabricating miniaturized probes is described that is suitable for targeting deep brain structure in the mouse.

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Design Fabrication Ultralight Weight Adjustable Multi-electrode Probes Electrophysiological Recordings Mice Physiological Investigations Genetic Targeting Microcircuit Dissection Disease Modeling Optogenetics Bidirectional Manipulation Temporal Resolution Brain Microcircuits Ensembles Of Neurons Head-fixed Preparation Freely Behaving Preparation Deep Structures Distinct Cell Layers Electrode Advancement Neural Ensembles Independently Movable Electrodes Lightweight Electrode Drive Resilience Customization Brain Structures
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