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Ammide Accoppiamento di reazione per la sintesi di leganti a base di Bispyridine e il loro Complessazione di platino come diciclici agenti antitumorali
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Ammide Accoppiamento di reazione per la sintesi di leganti a base di Bispyridine e il loro Complessazione di platino come diciclici agenti antitumorali

Article DOI: 10.3791/51740-v • 07:20 min • May 28th, 2014
May 28th, 2014 •
1, 2, 3, 4, 1
1Faculty of Pharmacy, The University of Sydney, 2School of Science and Health, University of Western Sydney, 3Division of Chemistry and Environmental Science, School of Science and the Environment, Manchester Metropolitan University, 4Nature Publishing Group

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Questo protocollo descrive l'uso di reazioni di accoppiamento ammide di acido isonicotinico e diaminoalkanes per formare leganti a ponte adatto per l'uso nella sintesi di complessi di platino multinucleate, che combinano aspetti dei farmaci antitumorali BBR3464 e picoplatin.

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Chimica BBR3464 picoplatin bispyridine giunto ammide sintesi inorganica il cancro
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