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Amidekoppeling reactie voor de synthese van Bispyridine-gebaseerde liganden en hun Complexatie naar Platinum als dinucleair antikankermiddelen
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Amidekoppeling reactie voor de synthese van Bispyridine-gebaseerde liganden en hun Complexatie naar Platinum als dinucleair antikankermiddelen

Article DOI: 10.3791/51740-v • 07:20 min • May 28th, 2014
May 28th, 2014 •
1, 2, 3, 4, 1
1Faculty of Pharmacy, The University of Sydney, 2School of Science and Health, University of Western Sydney, 3Division of Chemistry and Environmental Science, School of Science and the Environment, Manchester Metropolitan University, 4Nature Publishing Group

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Dit protocol beschrijft het gebruik van amide koppelingsreacties van isonicotinezuur en diaminoalkanes te overbruggen liganden geschikt voor gebruik in de synthese van meerkernige platina complexen, die aspecten van de antikankergeneesmiddelen BBR3464 en picoplatin combineren vormen.

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Chemie BBR3464 picoplatin bispyridine amide koppeling anorganische synthese kanker
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