Modellazione Astrocitoma Patogenesi<em> In Vitro</em> E<em> In Vivo</em> Utilizzo corticale astrociti o cellule staminali neurali da condizionale, topi geneticamente ingegnerizzati
Phenotypically wild-type astrocytes and neural stem cells harvested from mice engineered with floxed, conditional oncogenic alleles and transformed via viral Cre-mediated recombination can be used to model astrocytoma pathogenesis in vitro and in vivo by orthotopic injection of transformed cells into brains of syngeneic, immune-competent littermates.