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JoVE Journal Neuroscience
Optogenetic Stimulation of the Auditory Nerve
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Optogenetic Stimulation of the Auditory Nerve

Article DOI: 10.3791/52069-v • 10:53 min • October 8th, 2014
October 8th, 2014 •
1,2,5, 1,3, 3, 1, 1, 3, 1,2,4
1InnerEarLab, Department of Otolaryngology, University Medical Center Goettingen, 2Bernstein Focus for Neurotechnology, University of Goettingen, 3Auditory Systems Physiology Group, Department of Otolaryngology, University Medical Center Goettingen, 4Center for Nanoscale Microscopy and Molecular Physiology of the Brain, University of Goettingen, 5Department of Chemical, Electronic, and Biomedical Engineering, University of Guanajuato

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Summary
Automatic Translation

Cochlear implants (CIs) enable hearing by direct electrical stimulation of the auditory nerve. However, poor frequency and intensity resolution limits the quality of hearing with CIs. Here we describe optogenetic stimulation of the auditory nerve in mice as an alternative strategy for auditory research and developing future CIs.

Tags

Optogenetic Stimulation Auditory Nerve Electrical Stimulation Cochlear Implants Sound Coding Frequency Resolution Intensity Resolution Current Spread Tonotopic Axis Optical Stimulation Infrared Illumination Higher Energy Underlying Mechanism Low Intensity Blue Light Channelrhodopsin 2 (ChR2) CatCh Variant Micro-light Emitting Diodes (µLEDs) Fiber-coupled Lasers Artificial Opening (cochleostomy) Round Window Light-evoked Potentials (optogenetic Auditory Brainstem Response: OABR) Microelectrode Recordings Acoustic
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