Porous Silicon Microparticles for Delivery of siRNA Therapeutics

Jianliang Shen; Xiaoyan Wu; Yeonju Lee; Joy Wolfram; Zhizhou Yang; Zong-Wan Mao; Mauro Ferrari; Haifa Shen

doi:10.3791/52075

Journal

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Bioengineering

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Porous Silicon Microparticles for Delivery of siRNA Therapeutics

JoVE Journal
Bioengineering

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JoVE Journal Bioengineering

Porous Silicon Microparticles for Delivery of siRNA Therapeutics

10,860 Views

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08:31 min

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January 15, 2015

DOI:

10.3791/52075-v

DOI:

10.3791/52075-v

•

08:31 min

January 15, 2015

•

5 Views

Jianliang Shen*^1,2, Xiaoyan Wu*^1,3, Yeonju Lee¹, Joy Wolfram^1,4, Zhizhou Yang¹, Zong-Wan Mao², Mauro Ferrari^1,5, Haifa Shen^1,6

¹Department of Nanomedicine,Houston Methodist Research Institute, ²MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry and Chemical Engineering,Sun Yat-sen University, ³Pediatrics Department of Union Hospital,Huazhong University of Science and Technology, ⁴CAS Key Laboratory for Biomedical Effects of Nanomaterials & Nanosafety,National Center for Nanoscience & Technology of China, ⁵Department of Medicine,Weill Cornell Medical College, ⁶Department of Cell and Developmental Biology,Weill Cornell Medical College

Summary

Delivery remains the main challenge for the therapeutic implementation of small interfering RNA (siRNA). This protocol involves the use of a multifunctional and biocompatible siRNA delivery platform, consisting of arginine and polyethylenimine grafted porous silicon microparticles.