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JoVE Journal Medicine
Ex vivo Behandling svar av primära tumörer och / eller associerade Metastaser för preklinisk och klinisk utveckling av Therapeutics
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Ex vivo Behandling svar av primära tumörer och / eller associerade Metastaser för preklinisk och klinisk utveckling av Therapeutics

Article DOI: 10.3791/52157
October 2nd, 2014 •
*1, *2, 3, 4, 5, 5, 2, 6
1Department of Pathology, Memorial Sloan Kettering Cancer Center, 2Molecular Pharmacology and Chemistry Program, Memorial Sloan Kettering Cancer Center, 3Department of Radiology, Weill Cornell Medical College, 4Department of Medicine, Memorial Sloan Kettering Cancer Center, 5Department of Oncology, Memorial Sloan Kettering Cancer Center, 6Department of Surgery, Memorial Sloan Kettering Cancer Center
* These authors contributed equally

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October 2nd, 2014

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Etablerade cancer cellinjer och xenotransplantat varit stöttepelaren i cancerforskning under de senaste decennierna. Dock tyder nya bevis som terapeutiskt svar i hög grad påverkas av tumörcellsmikromiljö. Därför har vi tagit fram en ex vivo analys av primära tumörprover för drogutvecklingsändamål.

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