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Journal / Immunology and Infection / Upptäckt av HLA-antigen Biomarkers i bröstcancer…
JoVE Journal
Immunology and Infection

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JoVE Journal Immunology and Infection
Upptäckt av HLA-antigen Biomarkers i bröstcancer Använda Label fria Biosensor Teknik
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Upptäckt av HLA-antigen Biomarkers i bröstcancer Använda Label fria Biosensor Teknik

Article DOI: 10.3791/52159-v • 08:27 min • March 24th, 2015
March 24th, 2015 •
1, 1, 1, 1, 1, 2, 2, 2,3, 1
1Experimmune, A Center for Immunotherapeutic Development, Department of Immunotherapeutics and Biotechnology, Texas Tech University Health Sciences Center, 2Resonant Sensors Incorporated, 3University of Texas Arlington

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Intakta klass I HLA / peptidkomplex fälls av cancerceller, vilket motsvarar en potentiell relevant cancer biomarkör. Använda märkningsfri sensorteknik och T-cellreceptor mimicking monoklonala antikroppar, detektion av skjul MIF / HLA-A * 02: 01 komplex i MDA-MB-231-cellsupernatanter, spetsade humanserum, och patientplasma demonstreras, vilket möjliggör utveckling av en roman cancer diagnostisk plattform.

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Immunologi HLA biomarkör bröstcancer TCRm diagnostik etikett-fri monoklonal antikropp
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