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Method of Isolated Ex Vivo Lung Perfusion in a Rat Model: Lessons Learned from Developing a Rat EVLP Program

Article DOI: 10.3791/52309-v • 08:59 min • February 25th, 2015
February 25th, 2015 •
1,2, 1,2, 3, 4, 2, 5,6, 3,7, *1,2,3, *2,3,4
1Department of Biomedical Engineering, Ohio State University Wexner Medical Center, 2Davis Heart & Lung Research Institute, Ohio State University Wexner Medical Center, 3The Collaboration for Organ Perfusion, Protection, Engineering and Regeneration (COPPER) Laboratory, Ohio State University Wexner Medical Center, 4Division of Cardiac Surgery, Department of Surgery, Ohio State University Wexner Medical Center, 5Departments of Pediatrics and Internal Medicine, Ohio State University, 6Advanced Lung Disease Program, Lung and Heart-Lung Transplant Programs, Nationwide Children's Hospital, 7Division of Transplantation, Department of Surgery, Ohio State University Wexner Medical Center
* These authors contributed equally

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Summary
Automatic Translation

Ex-Vivo Lung Perfusion (EVLP) has allowed lung transplantation in humans to become more readily available by enabling the ability to assess organs and expand the donor pool. Here, we describe the development of a rat EVLP program and refinements that allow for a reproducible model for future expansion.

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Ex Vivo Lung Perfusion EVLP Lung Transplantation Donor Lungs Organ Assessment Expanding Donor Pool Substandard Lungs Animal Model Improved Techniques Management Of Donated Lungs Lung-transplant Recipient Associated Pathologies Ventilation Induced Lung Injury Rat EVLP Lung Program VILI Model Research Community Robust And Reproducible EVLP System
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