JoVE Journal
Developmental Biology
Developmental Biology
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基于发育毒性测定化学品安全筛选和系统生物学数据生成人类多能干细胞
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Article
DOI:
10.3791/52333-v
•
17:28 min
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June 17th, 2015
基于发育毒性测定化学品安全筛选和系统生物学数据生成人类多能干细胞
June 17th, 2015
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Vaibhav Shinde*1, Stefanie Klima*2, Perumal Srinivasan Sureshkumar1, Kesavan Meganathan1, Smita Jagtap1, Eugen Rempel3, Jörg Rahnenführer3, Jan Georg Hengstler4, Tanja Waldmann2, Jürgen Hescheler1, Marcel Leist*2, Agapios Sachinidis*1
1Center of Physiology and Pathophysiology, Institute of Neurophysiology, University of Cologne, 2Department of Biology, University of Konstanz, 3Department of Statistics, Technical University of Dortmund, 4Leibniz Research Centre for Working Environment and Human Factors, Technical University of Dortmund
* These authors contributed equally
Chapters
Summary
Please note that all translations are automatically generated.
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该协议描述了基于人胚胎干细胞和转录研究2 在体外发育毒性试验系统(UKK和UKN1)。测试系统预测人类发育毒性危险,并可能有助于减少动物研究中,成本和所需的化学安全测试的时间。