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Methoden zur Zytotoxizität und Immunsuppression mit brennbarem Tabakwaren Vorbereitungen Bewerten
JoVE Journal
Immunology and Infection
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JoVE Journal Immunology and Infection
Methods to Evaluate Cytotoxicity and Immunosuppression of Combustible Tobacco Product Preparations

Methoden zur Zytotoxizität und Immunsuppression mit brennbarem Tabakwaren Vorbereitungen Bewerten

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09:25 min

January 10, 2015

DOI:

09:25 min
January 10, 2015

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Summary

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Using optimized human peripheral blood mononuclear cell (PBMC) ex vivo assays, we showed that a combustible tobacco product preparation markedly suppresses receptor-mediated intracellularly secreted cytokines and cytolytic ability of effector PBMCs. These rapid assays may be useful in product evaluation and understanding the potential long-term effects of tobacco exposure.

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